NCBI list of publications

  1. Barkal LJ, Berthier E, Theberge AB, Keller NP, Beebe DJ. Multikingdom microscale models. PLoS Pathog. 2017 Aug 24; 13(8): e1006424. doi: 10.1371/journal/ppat.1006424. PMID: 28837694.

  2. Powell D, Tauzin S, Hind LE, Deng Q, Beebe DJ, Huttnelocher A. Chemokine Signaling and the Regulation of Bidirectional Leukocyte Migration in Interstitial Tissues. Cell Rep. 2017 May 23;19(8):1572-1585. doi: 10.1016/j.celrep.2017.04.078. PMID: 28528177

  3. Tokar JJ, Warrick JW, Guckenberger DJ, Sperger JM, Lang JM, Ferguson JS, Beebe DJ. Interrogating Bronchoalveolar Lavage Samples via Exclusion-Based Analyte Extraction. SLAS Technol. 2017 Jun 22(3): 348-357. doi: 10.1177/2472630317696780. Epub 2017 Mar 15. PMID: 28298147

  4. Regier MC, Montanez-Sauri SI, Schwartz MP, Murphy WL, Beebe DJ, Sung KE. The Influence of Biomaterials on Cytokine Production in 3D Cultures. Biomacromolecules. 2017 Mar 13; 18(3): 709-18. doi: 10.1021/acs.biomac.6b01469. Epub 2017 Feb 16. PMID: 28157290

  5. Johnson CJ, Cabezas-Olcoz J, Kemien JF, Wang SX, Beebe DJ, Huttenlocher A, Ansari H, Nett JE. The Extracellular Matrix of Candida albicans Biofilms Impairs Formation of Neutrophil Extracellular Traps. PLoS Pathog. 2016 Sep 13; 12(9)e1005884. doi: 10.1371/journal.ppat.1005884. PMID: 27622514

  6. Guckenberger DJ, Pezzi HM, Regier MC, Berry SM, Fawcett K, Barrett K, Beebe DJ. A magnetic system for automated manipulation of paramagnetic particles. Anal Chem. Epub 2016 Sep 6.  PMID: 2759885

  7. Jiménez-Torres JA, Beebe DJ, Sung KE. A Microfluidic Method to Mimic Luminal Structures in the Tumor Microenvironment. Methods Mol Biol. 2016;1458:59-69. doi: 10.1007/978-1-4939-3801-8_5. PMID: 2758101

  8. Regier MC, Maccoux LJ, Weinberger EM, Regehr KJ, Berry SM, Beebe DJ, Alarid ET.  Transitions from mono- to co- to tri-culture uniquely affect gene expression in breast cancer, stromal, and immune compartments. Biomed Microdevices. 2016 Aug;18(4):70. doi: 10.1007/s10544-016-0083-x. PMID: 2743232

  9. Schehr JL, Schultz ZD, Warrick JW, Guckenberger DJ, Pezzi HM, Sperger JM, Heninger E, Saeed A, Leal T, Mattox K, Traynor AM, Campbell TC, Berry SM, Beebe DJ, Lang JM. High Specificity in Circulating Tumor Cell Identification Is Required for Accurate Evaluation of Programmed Death-Ligand 1. PLoS One. 2016 Jul 26;11(7):e0159397. doi: 10.1371/journal.pone.0159397. eCollection 2016. PMID: 2745954

  10. Sperger JM, Strotman LN, Welsh A, Casavant BP, Chalmers Z, Horn S, Heninger E, Thiede S, Tokar J, Gibbs BK, Guckenberger DJ, Carmichael L, Dehm SM, Stephens PJ, Beebe DJ, Berry SM, Lang JM. Integrated analysis of multiple biomarkers from circulating tumor cells enabled by exclusion-based analyte isolation. Clin Cancer Res. 2016 Jul 11. pii: clincanres.1021.2016. [Epub ahead of print] PMID: 2740124

  11. Regier MC, Alarid ET, Beebe DJ. Progress towards understanding heterotypic interactions in multi-culture models of breast cancer.Integr Biol (Camb). 2016 Jun 13;8(6):684-92. doi: 10.1039/c6ib00001k. Epub 2016 Apr 21. PubMed PMID: 27097801

  12. Berry SM, Pezzi HM, LaVanway AJ, Guckenberger DJ, Anderson MA, Beebe DJ. AirJump: Using Interfaces to Instantly Perform Simultaneous Extractions. ACS Appl Mater Interfaces. 2016 Jun 10. [Epub ahead of print] PubMed Central PMCID: 5058634.

  13. Morgan MM, Johnson BP, Livingston MK, Schuler LA, Alarid ET, Sung KE, Beebe DJ. Personalized in vitro cancer models to predict therapeutic response: Challenges and a framework for improvement. Pharmacol Ther. 2016 May 21. pii: S0163-7258(16)30078-X. doi: 10.1016/j.pharmthera.2016.05.007. [Epub ahead of print] Review. PubMed PMID: 27218886.

  14. Barkal LJ, Walsh NM, Botts MR, Beebe DJ, Hull CM. Leveraging a high resolution microfluidic assay reveals insights into pathogenic fungal spore germination. Integr Biol (Camb). 2016 May 16;8(5):603-15. doi: 10.1039/c6ib00012f. Epub 2016 Mar 30. PubMed PMID: 27026574; PubMed Central PMCID: PMC4868663

  15. Zanotelli MR, Ardalani H, Zhang J, Hou Z, Nguyen EH, Swanson S, Nguyen BK, Bolin J, Elwell A, Bischel LL, Xie AW, Stewart R, Beebe DJ, Thomson JA, Schwartz MP, Murphy WL. Stable engineered vascular networks from human induced pluripotent stem cell-derived endothelial cells cultured in synthetic hydrogels. Acta Biomater. 2016. doi: 10.1016/j.actbio.2016.03.001. PubMed PMID: 26945632

  16. Barkal LJ, Theberge AB, Guo CJ, Spraker J, Rappert L, Berthier J, Brakke KA, Wang CC, Beebe DJ, Keller NP, Berthier E. Microbial metabolomics in open microscale platforms. Nat Commun. 2016 Feb 4;7:10610. doi: 10.1038/ncomms10610. PubMed PMID: 26842393.

  17. Moussavi-Harami SF, Mladinich KM, Sackmann EK, Shelef MA, Starnes TW, Guckenberger DJ, Huttenlocher A, Beebe DJ. Microfluidic device for simultaneous analysis of neutrophil extracellular traps and production of reactive oxygen species. Integr Biol (Camb). 2016 Feb 15;8(2):243-52. doi: 10.1039/c5ib00225g. Epub 2016 Jan 25. PubMed PMID: 26805445.

  18. Jiménez-Torres JA, Peery SL, Sung KE, Beebe DJ. LumeNEXT: A Practical Method to Pattern Luminal Structures in ECM Gels. Adv Healthc Mater. 2016 Jan;5(2):198-204. doi: 10.1002/adhm.201500608. Epub 2015 Nov 26. PubMed PMID: 26610188.
  19. Hong, WS, Pezzi HM, Schuster AR, Berry SM, Sung KE, Beebe DJ.  Development of a Highly Sensitive Cell-Based Assay for Detecting Botulinum Neurotoxin Type A through Neural Culture Media Optimization. J Biomol Screen. 2016 Jan;21(1):65-73. doi: 10.1177/1087057115608103. PubMed PMID: 26420788.
  20. Khnouf R, Chapman B, Jin S, Beebe DJ, Fan ZH. Detection of ricin in beverages using cell-free protein synthesis in a microfluidic device. Sensors and Actuators B: Chemical. 2015; Dec; 221:723-729. doi:10.1016/j.snb.2015.06.077.
  21. de Groot TE, Veserat KS, Berthier E, Beebe DJ, Theberge AB. Surface-tension driven open microfluidic platform for hanging droplet culture. Lab Chip. 2015 Dec 11. [Epub ahead of print] PubMed PMID: 26660268.
  22. Yamahashi Y, Cavnar PJ, Hind LE, Berthier E, Bennin DA, Beebe D, Huttenlocher A. Integrin associated proteins differentially regulate neutrophil polarity and directed migration in 2D and 3D. Biomed Microdevices. 2015 Oct;17(5):100. doi: 10.1007/s10544-015-9998-x. PubMed PMID: 26354879; PubMed Central PMCID: PMC4678772.
  23. Pak C, Callander NS, Young EW, Titz B, Kim K, Saha S, Chng K, Asimakopoulos F, Beebe DJ, Miyamoto S. MicroC(3): an ex vivo microfluidic cis-coculture assay to test chemosensitivity and resistance of patient multiple myeloma cells. Integr Biol (Camb). 2015 Jun 8;7(6):643-54. doi: 10.1039/c5ib00071h. Epub 2015 May 22. PubMed PMID: 25998180; PubMed Central PMCID: PMC4476551.
  24. Guckenberger DJ, de Groot TE, Wan AM, Beebe DJ, Young EW. Micromilling: a method for ultra-rapid prototyping of plastic microfluidic devices. Lab Chip. 2015 Jun 7;15(11):2364-78. doi: 10.1039/c5lc00234f. PubMed PMID: 25906246; PubMed Central PMCID: PMC4439323.
  25. Moussavi-Harami SF, Pezzi HM, Huttenlocher A, Beebe DJ. Simple microfluidic device for studying chemotaxis in response to dual gradients. Biomed Microdevices. 2015 Jun;17(3):9955. doi: 10.1007/s10544-015-9955-8. PubMed PMID: 25893484.
  26. Theberge AB, Yu J, Young EW, Ricke WA, Bushman W, Beebe DJ. Microfluidic multiculture assay to analyze biomolecular signaling in angiogenesis. Anal Chem. 2015 Mar 17;87(6):3239-46. doi: 10.1021/ac503700f. Epub 2015 Feb 26. PubMed PMID: 25719435; PubMed Central PMCID: PMC4405103.
  27. Bischel LL, Beebe DJ, Sung KE. Microfluidic model of ductal carcinoma in situ with 3D, organotypic structure. BMC Cancer. 2015. Jan 21; 15:12. doi: 10.1186/s12885-015-1007-5. PubMed PMID: 25605670; PubMed Central PMCID: PMC4305264.
  28.  Powers GL, Hammer KD, Domenech M, Frantskevich K, Malinowski RL, Bushman W, Beebe DJ, Marker PC. Phosphodiesterase 4D inhibitors limit prostate cancer growth potential. Molecular cancer research : MCR. 2015;13(1):149-60. Epub 2014/08/26. doi: 10.1158/1541-7786.MCR-14-0110. PubMed PMID: 25149359; 4312503
  29. Montanez-Sauri SI, Beebe DJ, Sung KE. Microscale screening systems for 3D cellular microenvironments: platforms, advances, and challenges. Cellular and molecular life sciences : CMLS. 2015;72(2):237-49. Epub 2014/10/03. doi: 10.1007/s00018-014-1738-5. PubMed PMID: 25274061
  30. Sung KE, Beebe DJ. Microfluidic 3D models of cancer. Adv Drug Deliv Rev. 2014;79-80:68-78. Epub 2014/07/16. doi: 10.1016/j.addr.2014.07.002. PubMed PMID: 25017040; 4258433
  31. Wan J, Zhu F, Zasadil LM, Yu J, Wang L, Johnson A, Berhtier E, Beebe DJ, Audhya A, Weaver BA. A Golgi-localized pool of the mitotic checkpoint component Mad1 controls integrin secretion and cell migration. Curr Biol. 2014;24(22):2687-92.
  32. Shelef M, Sokolove J, Lahey L, Wagner C, Sackmann E, Warner T, Wang Y, Beebe D, Robinson W, Huttenlocher A. Peptidylarginine Deiminase 4 Contributes to Tumor Necrosis Factor alpha-Induced Inflammatory Arthritis. Arthritis & Rheumatology. 2014;66(6):1482-91. doi: 10.1002/art.38393. PubMed PMID: WOS:000337366200010
  33. Sackmann E, Fulton A, Beebe D. The present and future role of microfluidics in biomedical research. Nature. 2014;507(7491):181-9. doi: 10.1038/nature13118. PubMed PMID: WOS:000332651800029
  34. Sackmann E, Berthier E, Schwantes E, Fichtinger P, Evans M, Dziadzio L, Huttenlocher A, Mathur S, Beebe D. Characterizing asthma from a drop of blood using neutrophil chemotaxis. Proceedings of the National Academy of Sciences of the United States of America. 2014;111(16):5813-8. doi: 10.1073/pnas.1324043111. PubMed PMID: WOS:000334694000032
  35. Montanez-Sauri SI, Beebe DJ, Sung KE. Microscale screening systems for 3D cellular microenvironments: platforms, advances, and challenges. Cellular and molecular life sciences : CMLS. 2014. Epub 2014/10/03. doi: 10.1007/s00018-014-1738-5. PubMed PMID: 25274061
  36. Howard A, Pezzi H, Beebe D, Berry S. Exclusion-Based Capture and Enumeration of CD4(+) T Cells from Whole Blood for Low-Resource Settings. Jala. 2014;19(3):313-21. doi: 10.1177/2211068213509248. PubMed PMID: WOS:000336267600010
  37.  Guckenberger D, Thomas P, Rothbauer J, LaVanway A, Anderson M, Gilson D, Fawcett K, Berto T, Barrett K, Beebe D, Berry S. A Combined Fabrication and Instrumentation Platform for Sample Preparation. Jala. 2014;19(3):267-74. doi: 10.1177/2211068213518312. PubMed PMID: WOS:000336267600005
  38. Guckenberger D, Berthier E, Young E, Beebe D. Fluorescence-Based Assessment of Plasma-Induced Hydrophilicity in Microfluidic Devices via Nile Red Adsorption and Depletion. Analytical Chemistry. 2014;86(15):7258-63. doi: 10.1021/ac501259n. PubMed PMID: WOS:000340081100018
  39. Fan Z, Beebe D. Lab on a chip and circulating tumor cells. Lab on a Chip. 2014;14(1):12-3. doi: 10.1039/c3lc90125d. PubMed PMID: WOS:000327669000001
  40. Casavant B, Strotman L, Tokar J, Thiede S, Traynor A, Ferguson J, Lang J, Beebe D. Paired diagnostic and pharmacodynamic analysis of rare non-small cell lung cancer cells enabled by the VerIFAST platform. Lab on a Chip. 2014;14(1):99-105. doi: 10.1039/c3lc50912e. PubMed PMID: WOS:000327669000010
  41. Casavant B, Guckenberger D, Beebe D, Berry S. Efficient Sample Preparation from Complex Biological Samples Using a Sliding Lid for Immobilized Droplet Extractions. Analytical Chemistry. 2014;86(13):6355-62. doi: 10.1021/ac500574t. PubMed PMID: WOS:000338488800028
  42. Carney CM, Muszynski JL, Strotman LN, Lewis SR, O'Connell RL, Beebe DJ, Theberge AB, Jorgensen JS. Cellular microenvironment dictates androgen production by murine fetal leydig cells in primary culture. Biol Reprod. 2014;91(4):85. Epub 2014/08/22. doi: 10.1095/biolreprod.114.118570. PubMed PMID: 25143354
  43. Bischel LL, Sung KE, Jimenez-Torres JA, Mader B, Keely PJ, Beebe DJ. The importance of being a lumen. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2014;28(11):4583-90. Epub 2014/08/01. doi: 10.1096/fj.13-243733. PubMed PMID: 25077562; 4200326
  44. Bischel L, Casavant B, Young P, Eliceiri K, Basu H, Beebe D. A microfluidic coculture and multiphoton FAD analysis assay provides insight into the influence of the bone microenvironment on prostate cancer cells. Integrative Biology. 2014;6(6):627-35. doi: 10.1039/c3ib40240a. PubMed PMID: WOS:000336835100006
  45. Berthier E, Beebe D. Gradient generation platforms: new directions for an established microfluidic technology. Lab on a Chip. 2014;14(17):3241-7. doi: 10.1039/c4lc00448e. PubMed PMID: WOS:000340204300016
  46. Berry S, Singh C, Lang J, Strotman L, Alarid E, Beebe D. Streamlining gene expression analysis: integration of co-culture and mRNA purification. Integrative Biology. 2014;6(2):224-31. doi: 10.1039/c3ib40136g. PubMed PMID: WOS:000330795500011
  47. Berry S, LaVanway A, Pezzi H, Guckenberger D, Anderson M, Loeb J, Beebe D. HIV Viral RNA Extraction in Wax Immiscible Filtration Assisted by Surface Tension (IFAST) Devices. Journal of Molecular Diagnostics. 2014;16(3):297-304. doi: 10.1016/j.jmoldx.2014.01.004. PubMed PMID: WOS:000335540200003
  48. Berry S, Chin E, Jackson S, Strotman L, Goel M, Thompson N, Alexander C, Miyamoto S, Burgess R, Beebe D. Weak protein-protein interactions revealed by immiscible filtration assisted by surface tension. Analytical Biochemistry. 2014;447:133-40. doi: 10.1016/j.ab.2013.10.038. PubMed PMID: WOS:000330089500022
  49. Young E, Berthier E, Beebe D. Assessment of Enhanced Autofluorescence and Impact on Cell Microscopy for Microfabricated Thermoplastic Devices. Analytical Chemistry. 2013;85(1):44-9. doi: 10.1021/ac3034773. PubMed PMID: WOS:000313156500010
  50. Warrick J, Young E, Schmuck E, Saupe K, Beebe D. High-content adhesion assay to address limited cell samples. Integrative Biology. 2013;5(4):720-7. doi: 10.1039/c3ib20224k. PubMed PMID: WOS:000316692700009
  51. Thomas P, Strotman L, Theberge A, Berthier E, O'Connell R, Loeb J, Berry S, Beebe D. Nucleic Acid Sample Preparation Using Spontaneous Biphasic Plug Flow. Analytical Chemistry. 2013;85(18):8641-6. doi: 10.1021/ac4012914. PubMed PMID: WOS:000330017400024
  52. Sung K, Su X, Berthier E, Pehlke C, Friedl A, Beebe D. Understanding the Impact of 2D and 3D Fibroblast Cultures on In Vitro Breast Cancer Models. Plos One. 2013;8(10). doi: 10.1371/journal.pone.0076373. PubMed PMID: WOS:000325489100107
  53. Su X, Theberge A, January C, Beebe D. Effect of Microculture on Cell Metabolism and Biochemistry: Do Cells Get Stressed in Microchannels? Analytical Chemistry. 2013;85(3):1562-70. doi: 10.1021/ac3027228. PubMed PMID: WOS:000314676100047
  54. Strotman L, O'Connell R, Casavant B, Berry S, Sperger J, Lang J, Beebe D. Selective Nucleic Acid Removal via Exclusion (SNARE): Capturing mRNA and DNA from a Single Sample. Analytical Chemistry. 2013;85(20):9764-70. doi: 10.1021/ac402162r. PubMed PMID: WOS:000326126600049
  55. Schwartz M, Rogers R, Singh S, Lee J, Loveland S, Koepsel J, Witze E, Montanez-Sauri S, Sung K, Tokuda E, Sharma Y, Everhart L, Nguyen E, Zaman M, Beebe D, Ahn N, Murphy W, Anseth K. A Quantitative Comparison of Human HT-1080 Fibrosarcoma Cells and Primary Human Dermal Fibroblasts Identifies a 3D Migration Mechanism with Properties Unique to the Transformed Phenotype. Plos One. 2013;8(12). doi: 10.1371/journal.pone.0081689. PubMed PMID: WOS:000327947800054
  56. Moussavi-Harami S, Annis D, Ma W, Berry S, Coughlin E, Strotman L, Maurer L, Westphall M, Coon J, Mosher D, Beebe D. Characterization of Molecules Binding to the 70K N-Terminal Region of Fibronectin by IFAST Purification Coupled with Mass Spectrometry. Journal of Proteome Research. 2013;12(7):3393-404. doi: 10.1021/pr400225p. PubMed PMID: WOS:000321605700030
  57. Montanez-Sauri S, Sung K, Berthier E, Beebe D. Enabling screening in 3D microenvironments: probing matrix and stromal effects on the morphology and proliferation of T47D breast carcinoma cells. Integrative Biology. 2013;5(3):631-40. doi: 10.1039/c3ib20225a. PubMed PMID: WOS:000315354900018
  58. Lang J, Casavant B, Berry S, Strotman L, Thiede S, Sperger J, Liu G, Beebe D. Nuclear localization of the androgen receptor in prostate cancer circulating tumor cells from men who have failed androgen deprivation therapy. Journal of Clinical Oncology. 2013;31(15). PubMed PMID: WOS:000335419605265
  59. Lang J, Berry S, Powers G, Beebe D, Alarid E. Hormonally responsive breast cancer cells in a microfluidic co-culture model as a sensor of microenvironmental activity. Integrative Biology. 2013;5(5):807-16. doi: 10.1039/c3ib20265h. PubMed PMID: WOS:000318302100006
  60. Hong W, Young E, Tepp W, Johnson E, Beebe D. A Microscale Neuron and Schwann Cell Coculture Model for Increasing Detection Sensitivity of Botulinum Neurotoxin Type A. Toxicological Sciences. 2013;134(1):64-72. doi: 10.1093/toxsci/kft082. PubMed PMID: WOS:000320907900006
  61. Casavant B, Mosher R, Warrick J, Maccoux L, Berry S, Becker J, Chen V, Lang J, McNeel D, Beebe D. A negative selection methodology using a microfluidic platform for the isolation and enumeration of circulating tumor cells. Methods. 2013;64(2):137-43. doi: 10.1016/j.ymeth.2013.05.027. PubMed PMID: WOS:000327567400007
  62. Casavant B, Guckenberger D, Berry S, Tokar J, Lang J, Beebe D. The VerIFAST: an integrated method for cell isolation and extracellular/intracellular staining. Lab on a Chip. 2013;13(3):391-6. doi: 10.1039/c2lc41136a. PubMed PMID: WOS:000312947300010
  63. Casavant B, Berthier E, Theberge A, Berthier J, Montanez-Sauri S, Bischel L, Brakke K, Hedman C, Bushman W, Keller N, Beebe D. Suspended microfluidics. Proceedings of the National Academy of Sciences of the United States of America. 2013;110(25):10111-6. doi: 10.1073/pnas.1302566110. PubMed PMID: WOS:000321500200030
  64. Bischel L, Young E, Mader B, Beebe D. Tubeless microfluidic angiogenesis assay with three-dimensional endothelial-lined microvessels. Biomaterials. 2013;34(5):1471-7. doi: 10.1016/j.biomaterials.2012.11.005. PubMed PMID: WOS:000313929400003
  65. Bischel L, Mader B, Green J, Huttenlocher A, Beebe D. Zebrafish Entrapment By Restriction Array (ZEBRA) device: a low-cost, agarose-free zebrafish mounting technique for automated imaging. Lab on a Chip. 2013;13(9):1732-6. doi: 10.1039/c3lc50099c. PubMed PMID: WOS:000316962700009
  66. Berthier E, Lim F, Deng Q, Guo C, Kontoyiannis D, Wang C, Rindy J, Beebe D, Huttenlocher A, Keller N. Low-Volume Toolbox for the Discovery of Immunosuppressive Fungal Secondary Metabolites. Plos Pathogens. 2013;9(4). doi: 10.1371/journal.ppat.1003289. PubMed PMID: WOS:000318072700030
  67. Berthier E, Guckenberger D, Cavnar P, Huttenlocher A, Keller N, Beebe D. Kit-On-A-Lid-Assays for accessible self-contained cell assays. Lab on a Chip. 2013;13(3):424-31. doi: 10.1039/c2lc41019b. PubMed PMID: WOS:000312947300014
  68. Berry S, Regehr K, Casavant B, Beebe D. Automated Operation of Immiscible Filtration Assisted by Surface Tension (IFAST) Arrays for Streamlined Analyte Isolation. Jala. 2013;18(3):206-11. doi: 10.1177/2211068212462023. PubMed PMID: WOS:000325923700003
  69. Beebe D, Ingber D, den Toonder J. Organs on Chips 2013. Lab on a Chip. 2013;13(18):3447-8. doi: 10.1039/c3lc90080k. PubMed PMID: WOS:000323111300001
  70. Young E, Pak C, Kahl B, Yang D, Callander N, Miyamoto S, Beebe D. e-Blood Microscale functional cytomics for studying hematologic cancers. Blood. 2012;119(10):E76-E85. doi: 10.1182/blood-2011-10-384347. PubMed PMID: WOS:000301356000002
  71. Su G, Sung K, Beebe D, Friedl A. Functional Screen of Paracrine Signals in Breast Carcinoma Fibroblasts. Plos One. 2012;7(10). doi: 10.1371/journal.pone.0046685. PubMed PMID: WOS:000309831500057
  72. Strotman L, Lin G, Berry S, Johnson E, Beebe D. Facile and rapid DNA extraction and purification from food matrices using IFAST (immiscible filtration assisted by surface tension). Analyst. 2012;137(17):4023-8. doi: 10.1039/c2an35506j. PubMed PMID: WOS:000306932400022
  73. Sackmann E, Berthier E, Young E, Shelef M, Wernimont S, Huttenlocher A, Beebe D. Microfluidic kit-on-a-lid: a versatile platform for neutrophil chemotaxis assays. Blood. 2012;120(14):E45-E53. doi: 10.1182/blood-2012-03-416453. PubMed PMID: WOS:000311616900001
  74. Resto P, Berthier E, Beebe D, Williams J. An inertia enhanced passive pumping mechanism for fluid flow in microfluidic devices. Lab on a Chip. 2012;12(12):2221-8. doi: 10.1039/c2lc20858j. PubMed PMID: WOS:000304448700015
  75. Lee J, Kim Y, Beebe D, Kim B. Harnessing gravitational, hydrodynamic and negative dielectrophoretic forces for higher throughput cell sorting. Biochip Journal. 2012;6(3):229-39. doi: 10.1007/s13206-012-6305-2. PubMed PMID: WOS:000308779800005
  76. Lee A, Beebe D, Palecek S. Quantification of kinase activity in cell lysates via photopatterned macroporous poly(ethylene glycol) hydrogel arrays in microfluidic channels. Biomedical Microdevices. 2012;14(2):247-57. doi: 10.1007/s10544-011-9602-y. PubMed PMID: WOS:000301544500001
  77. Lang J, Casavant B, Beebe D. Circulating Tumor Cells: Getting More from Less. Science Translational Medicine. 2012;4(141). doi: 10.1126/scitranslmed.3004261. PubMed PMID: WOS:000306108800002
  78. Guckenberger D, Berthier E, Young E, Beebe D. Induced hydrophobic recovery of oxygen plasma-treated surfaces. Lab on a Chip. 2012;12(13):2317-21. doi: 10.1039/c2lc21052e. PubMed PMID: WOS:000305288600006
  79. Goel S, Chin E, Fakhraldeen S, Berry S, Beebe D, Alexander C. Both LRP5 and LRP6 Receptors Are Required to Respond to Physiological Wnt Ligands in Mammary Epithelial Cells and Fibroblasts. Journal of Biological Chemistry. 2012;287(20):16454-66. doi: 10.1074/jbc.M112.362137. PubMed PMID: WOS:000304030900036
  80. Domenech M, Bjerregaard R, Bushman W, Beebe D. Hedgehog signaling in myofibroblasts directly promotes prostate tumor cell growth. Integrative Biology. 2012;4(2):142-52. doi: 10.1039/c1ib00104c. PubMed PMID: WOS:000299640700003
  81. Cavnar P, Mogen K, Berthier E, Beebe D, Huttenlocher A. The Actin Regulatory Protein HS1 Interacts with Arp2/3 and Mediates Efficient Neutrophil Chemotaxis. Journal of Biological Chemistry. 2012;287(30):25466-77. doi: 10.1074/jbc.M112.364562. PubMed PMID: WOS:000306651700053
  82. Casavant B, Tokar J, Lang J, Abel E, Beebe D. Isolation of renal cell carcinoma cells from blood samples using the vertical immiscible filtration assisted by surface tension (VerIFAST) microfluidic platform. Bju International. 2012;110:3-. PubMed PMID: WOS:000308932400007
  83. Bischel L, Lee S, Beebe D. A Practical Method for Patterning Lumens through ECM Hydrogels via Viscous Finger Patterning. Jala. 2012;17(2):96-103. doi: 10.1177/2211068211426694. PubMed PMID: WOS:000304775300002
  84. Berry S, Maccoux L, Beebe D. Streamlining Immunoassays with Immiscible Filtrations Assisted by Surface Tension. Analytical Chemistry. 2012;84(13):5518-23. doi: 10.1021/ac300085m. PubMed PMID: WOS:000305871300012
  85. Young E, Berthier E, Guckenberger D, Sackmann E, Lamers C, Meyvantsson I, Huttenocher A, Beebe D. Rapid Prototyping of Arrayed Microfluidic Systems in Polystyrene for Cell-Based Assays. Analytical Chemistry. 2011;83(4):1408-17. doi: 10.1021/ac102897h. PubMed PMID: WOS:000287176900037
  86. Sung K, Yang N, Pehlke C, Keely P, Eliceiri K, Friedl A, Beebe D. Transition to invasion in breast cancer: a microfluidic in vitro model enables examination of spatial and temporal effects. Integrative Biology. 2011;3(4):439-50. doi: 10.1039/c0ib00063a. PubMed PMID: WOS:000289154600016
  87. Su X, Young E, Underkofler H, Kamp T, January C, Beebe D. Microfluidic Cell Culture and Its Application in High-Throughput Drug Screening: Cardiotoxicity Assay for hERG Channels. Journal of Biomolecular Screening. 2011;16(1):101-11. doi: 10.1177/1087057110386218. PubMed PMID: WOS:000286063300011
  88. Montanez-Sauri S, Sung K, Puccinelli J, Pehlke C, Beebe D. Automation of Three-Dimensional Cell Culture in Arrayed Microfluidic Devices. Jala. 2011;16(3):171-85. doi: 10.1016/j.jala.2011.02.003. PubMed PMID: WOS:000290826000002
  89. Kshitiz, Kim D, Beebe D, Levchenko A. Micro- and nanoengineering for stem cell biology: the promise with a caution. Trends in Biotechnology. 2011;29(8):399-408. doi: 10.1016/j.tibtech.2011.03.006. PubMed PMID: WOS:000293485300005
  90. Frisk M, Lin G, Johnson E, Beebe D. Synaptotagmin II peptide-bead conjugate for botulinum toxin enrichment and detection in microchannels. Biosensors & Bioelectronics. 2011;26(5):1929-35. doi: 10.1016/j.bios.2010.06.035. PubMed PMID: WOS:000286904400022
  91. Cavnar P, Berthier E, Beebe D, Huttenlocher A. Hax1 regulates neutrophil adhesion and motility through RhoA. Journal of Cell Biology. 2011;193(3):465-73. doi: 10.1083/jcb.201010143. PubMed PMID: WOS:000290676400007
  92. Berthier E, Warrick J, Casavant B, Beebe D. Pipette-friendly laminar flow patterning for cell-based assays. Lab on a Chip. 2011;11(12):2060-5. doi: 10.1039/c0lc00539h. PubMed PMID: WOS:000291166000015
  93. Berry S, Strotman L, Kueck J, Alarid E, Beebe D. Purification of cell subpopulations via immiscible filtration assisted by surface tension (IFAST). Biomedical Microdevices. 2011;13(6):1033-42. doi: 10.1007/s10544-011-9573-z. PubMed PMID: WOS:000297121700009
  94. Berry S, Alarid E, Beebe D. One-step purification of nucleic acid for gene expression analysis via Immiscible Filtration Assisted by Surface Tension (IFAST). Lab on a Chip. 2011;11(10):1747-53. doi: 10.1039/c1lc00004g. PubMed PMID: WOS:000289951200006
  95. Young E, Beebe D. Fundamentals of microfluidic cell culture in controlled microenvironments. Chemical Society Reviews. 2010;39(3):1036-48. doi: 10.1039/b909900j. PubMed PMID: WOS:000274920300012
  96. Puccinelli J, Su X, Beebe D. Automated High-Throughput Microchannel Assays for Cell Biology: Operational Optimization and Characterization. Jala. 2010;15(1):25-32. doi: 10.1016/j.jala.2009.10.002. PubMed PMID: WOS:000295434000004
  97. Paguirigan A, Puccinelli J, Su X, Beebe D. Expanding the Available Assays: Adapting and Validating In-Cell Westerns in Microfluidic Devices for Cell-Based Assays. Assay and Drug Development Technologies. 2010;8(5):591-601. doi: 10.1089/adt.2010.0274. PubMed PMID: WOS:000283438400006
  98. Lopez-Garcia M, Beebe D, Crone W. Mechanical Interactions of Mouse Mammary Gland Cells with Collagen in a Three-Dimensional Construct. Annals of Biomedical Engineering. 2010;38(8):2485-98. doi: 10.1007/s10439-010-0015-5. PubMed PMID: WOS:000279682000002
  99. Lopez-Garcia M, Beebe D, Crone W. Young's modulus of collagen at slow displacement rates. Bio-Medical Materials and Engineering. 2010;20(6):361-9. doi: 10.3233/bme-2010-0649. PubMed PMID: WOS:000286596200006
  100. Lee A, Arena C, Beebe D, Palecek S. Macroporous hydrogels for quantifying cancer-inducing kinase activity in microfluidic devices. Abstracts of Papers of the American Chemical Society. 2010;239. PubMed PMID: WOS:000208189300681
  101. Lee A, Arena C, Beebe D, Palecek S. Development of Macroporous Poly(ethylene glycol) Hydrogel Arrays within Microfluidic Channels. Biomacromolecules. 2010;11(12):3316-24. doi: 10.1021/bm100792y. PubMed PMID: WOS:000285267500012
  102. Ju J, Warrick J, Beebe D. A Cell Programmable Assay (CPA) chip. Lab on a Chip. 2010;10(16):2071-6. doi: 10.1039/c005103a. PubMed PMID: WOS:00028039480000
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  104. Bauer M, Su G, Beebe D, Friedl A. 3D microchannel co-culture: method and biological validation. Integrative Biology. 2010;2(7-8):371-8. doi: 10.1039/c0ib00001a. PubMed PMID: WOS:000280769200006
  105.  Zhu Y, Warrick J, Haubert K, Beebe D, Yin J. Infection on a chip: a microscale platform for simple and sensitive cell-based virus assays. Biomedical Microdevices. 2009;11(3):565-70. doi: 10.1007/s10544-008-9263-7. PubMed PMID: WOS:000265440300005
  106. Sung K, Su G, Pehlke C, Trier S, Eliceiri K, Keely P, Friedl A, Beebe D. Control of 3-dimensional collagen matrix polymerization for reproducible human mammary fibroblast cell culture in microfluidic devices. Biomaterials. 2009;30(27):4833-41. doi: 10.1016/j.biomaterials.2009.05.043. PubMed PMID: WOS:000269330400045
  107. Regehr K, Domenech M, Koepsel J, Carver K, Ellison-Zelski S, Murphy W, Schuler L, Alarid E, Beebe D. Biological implications of polydimethylsiloxane-based microfluidic cell culture. Lab on a Chip. 2009;9(15):2132-9. doi: 10.1039/b903043c. PubMed PMID: WOS:000268033900003
  108. Paguirigan A, Beebe D. From the cellular perspective: exploring differences in the cellular baseline in macroscale and microfluidic cultures. Integrative Biology. 2009;1(2):182-95. doi: 10.1039/b814565b. PubMed PMID: WOS:000267113600005
  109. Mohanty S, Warrick J, Gorski J, Beebe D. An accessible micro-capillary electrophoresis device using surface-tension-driven flow. Electrophoresis. 2009;30(9):1470-81. doi: 10.1002/elps.200800595. PubMed PMID: WOS:000266312800006
  110. Kim D, Lokuta M, Huttenlocher A, Beebe D. Selective and tunable gradient device for cell culture and chemotaxis study. Lab on a Chip. 2009;9(12):1797-800. doi: 10.1039/b901613a. PubMed PMID: WOS:000266616000021
  111. Khnouf R, Beebe D, Fan Z. Cell-free protein expression in a microchannel array with passive pumping. Lab on a Chip. 2009;9(1):56-61. doi: 10.1039/b808034h. PubMed PMID: WOS:000262649400009
  112. Frisk M, Tepp W, Johnson E, Beebe D. Self-Assembled Peptide Monolayers as a Toxin Sensing Mechanism within Arrayed Microchannels. Analytical Chemistry. 2009;81(7):2760-7. doi: 10.1021/ac802707u. PubMed PMID: WOS:000264759400046
  113. Domenech M, Yu H, Warrick J, Badders N, Meyvantsson I, Alexander C, Beebe D. Cellular observations enabled by microculture: paracrine signaling and population demographics. Integrative Biology. 2009;1(3):267-74. doi: 10.1039/b823059e. PubMed PMID: WOS:000267113900005
  114. Beebe D, Barcellos-Hoff M. The development of integrative biology: bridging the gap-a view from the Scientific Editors. Integrative Biology. 2009;1(2):145-7. doi: 10.1039/b822329g. PubMed PMID: WOS:000267113600001
  115. Paguirigan A, Beebe D. Microfluidics meet cell biology: bridging the gap by validation and application of microscale techniques for cell biological assays. Bioessays. 2008;30(9):811-21. doi: 10.1002/bies.20804. PubMed PMID: WOS:000258891400005
  116. Meyvantsson I, Warrick J, Hayes S, Skoien A, Beebe D. Automated cell culture in high density tubeless microfluidic device arrays. Lab on a Chip. 2008;8(5):717-24. doi: 10.1039/b715375a. PubMed PMID: WOS:000255276700012
  117. Meyvantsson I, Beebe D. Cell Culture Models in Microfluidic Systems. Annual Review of Analytical Chemistry. 2008;1:423-49. doi: 10.1146/annurev.anchem.1.031207.113042. PubMed PMID: WOS:000262525200014
  118. Lopez-Garcia M, Monson R, Haubert K, Wheeler M, Beebe D. Sperm motion in a microfluidic fertilization device. Biomedical Microdevices. 2008;10(5):709-18. doi: 10.1007/s10544-008-9182-7. PubMed PMID: WOS:000258581700012
  119. Kwon G, Park J, Kim J, Frisk M, Beebe D, Lee S. Biomimetic Soft Multifunctional Miniature Aquabots. Small. 2008;4(12):2148-53. doi: 10.1002/smll.200800315. PubMed PMID: WOS:000261905100012
  120. Kim D, Beebe D. Interfacial formation of porous membranes with poly(ethylene glycol) in a microfluidic environment. Journal of Applied Polymer Science. 2008;110(3):1581-9. doi: 10.1002/app.27890. PubMed PMID: WOS:000259168100038
  121. Ju J, Park J, Kim K, Kim H, Berthier E, Beebe D, Lee S. Backward flow in a surface tension driven micropump. Journal of Micromechanics and Microengineering. 2008;18(8). doi: 10.1088/0960-1317/18/8/087002. PubMed PMID: WOS:000257891600023
  122. Jongpaiboonkit L, King W, Lyons G, Paguirigan A, Warrick J, Beebe D, Murphy W. An adaptable hydrogel array format for 3-dimensional cell culture and analysis. Biomaterials. 2008;29(23):3346-56. doi: 10.1016/j.biomaterials.2008.04.040. PubMed PMID: WOS:000257344600007
  123. Frisk M, Berthier E, Tepp W, Johnson E, Beebe D. Bead-based microfluidic toxin sensor integrating evaporative signal amplification. Lab on a Chip. 2008;8(11):1793-800. doi: 10.1039/b811075a. PubMed PMID: WOS:000261686100010
  124. Berthier E, Warrick J, Yu H, Beebe D. Managing evaporation for more robust microscale assays - Part 2. Characterization of convection and diffusion for cell biology. Lab on a Chip. 2008;8(6):860-4. doi: 10.1039/b717423c. PubMed PMID: WOS:000256115200002
  125. Berthier E, Warrick J, Yu H, Beebe D. Managing evaporation for more robust microscale assays - Part 1. Volume loss in high throughput assays. Lab on a Chip. 2008;8(6):852-9. doi: 10.1039/b717422e. PubMed PMID: WOS:000256115200001
  126. Badders N, Yu H, Alexander C, Beebe D. Quantification of small cell numbers with a microchannel device. Biotechniques. 2008;45(3):321-+. doi: 10.2144/000112906. PubMed PMID: WOS:000263638100023
  127. Abhyankar V, Toepke M, Cortesio C, Lokuta M, Huttenlocher A, Beebe D. A platform for assessing chemotactic migration within a spatiotemporally defined 3D microenvironment. Lab on a Chip. 2008;8(9):1507-15. doi: 10.1039/b803533d. PubMed PMID: WOS:000259676000013
  128. Zheng T, Yu H, Alexander C, Beebe D, Smith L. Lectin-modified microchannels for mammalian cell capture and purification. Biomedical Microdevices. 2007;9(4):611-7. doi: 10.1007/s10544-007-9074-2. PubMed PMID: WOS:000248007500020
  129. Yu H, Alexander C, Beebe D. Understanding microchannel culture: parameters involved in soluble factor signaling. Lab on a Chip. 2007;7(6):726-30. doi: 10.1039/b618793e. PubMed PMID: WOS:000247566400020
  130. Yu H, Alexander C, Beebe D. A plate reader-compatible microchannel array for cell biology assays. Lab on a Chip. 2007;7(3):388-91. doi: 10.1039/b612358a. PubMed PMID: WOS:000244616900014
  131. Wheeler M, Walters E, Beebe D. Toward culture of single gametes: The development of microfluidic platforms for assisted reproduction. Theriogenology. 2007;68:S178-S89. doi: 10.1016/j.theriogenology.2007.04.042|10.1016/i.theriogenology.2007.04.042. PubMed PMID: WOS:000248916700023
  132. Warrick J, Meyvantsson I, Ju J, Beebe D. High-throughput microfluidics: improved sample treatment and washing over standard wells. Lab on a Chip. 2007;7(3):316-21. doi: 10.1039/b613350a. PubMed PMID: WOS:000244616900004
  133. Toepke M, Abhyankar V, Beebe D. Microfluidic logic gates and timers. Lab on a Chip. 2007;7(11):1449-53. doi: 10.1039/b708764k. PubMed PMID: WOS:000250428200016
  134. Paguirigan A, Beebe D, Alexander C. Simulating mouse mammary gland development: cell ageing and its relation to stem and progenitor activity. Cell Proliferation. 2007;40(1):106-24. PubMed PMID: WOS:000243442600009
  135. Paguirigan A, Beebe D. Protocol for the fabrication of enzymatically crosslinked gelatin microchannels for microfluidic cell culture. Nature Protocols. 2007;2(7):1782-8. doi: 10.1038/nprot.2007.256. PubMed PMID: WOS:000253139200024
  136. Lopez-Garcia M, Beebe D, Crone W. Characterization of poly(isobornyl acrylate) as a construction material for microfluidic applications. Journal of Applied Polymer Science. 2007;105(4):1894-902. doi: 10.1002/app.26195. PubMed PMID: WOS:000247576600022
  137. Kim D, Beebe D. Hydrogel-based reconfigurable components for microfluidic devices. Lab on a Chip. 2007;7(2):193-8. doi: 10.1039/b612995a. PubMed PMID: WOS:000244616300007
  138. Kim D, Beebe D. A bi-polymer micro one-way valve. Sensors and Actuators a-Physical. 2007;136(1):426-33. doi: 10.1016/j.sna.2006.11.004. PubMed PMID: WOS:000246463000057
  139. Frisk M, Tepp W, Lin G, Johnson E, Beebe D. Substrate-modified hydrogels for autonomous sensing of botulinum neurotoxin type A. Chemistry of Materials. 2007;19(24):5842-4. doi: 10.1021/cm7021032. PubMed PMID: WOS:000251150900014
  140. Dong L, Agarwal A, Beebe D, Jiang H. Variable-focus liquid microlenses and microlens arrays actuated by thermoresponsive hydrogels. Advanced Materials. 2007;19(3):401-+. doi: 10.1002/adma.200601561. PubMed PMID: WOS:000244217800013
  141. Berthier E, Beebe D. Flow rate analysis of a surface tension driven passive micropump. Lab on a Chip. 2007;7(11):1475-8. doi: 10.1039/b707637a. PubMed PMID: WOS:000250428200020
  142. Agarwal A, Dong L, Beebe D, Jiang H. Autonomously-triggered microfluidic cooling using thermo-responsive hydrogels. Lab on a Chip. 2007;7(3):310-5. doi: 10.1039/b617767k. PubMed PMID: WOS:000244616900003
  143. Agarwal A, Atencia J, Beebe D, Jiang H. Design of microfluidic impellers capable of bi-directional pumping under a single rotating magnetic actuation. Proceedings of the Ieee Twentieth Annual International Conference on Micro Electro Mechanical Systems, Vols 1 and 2. 2007:502-5. PubMed PMID: WOS:000255867800126
  144. Abhyankar V, Beebe D. Spatiotemporal micropatterning of cells on arbitrary substrates. Analytical Chemistry. 2007;79(11):4066-73. doi: 10.1021/ac062371p. PubMed PMID: WOS:000246842100011
  145. Wheeler M, Rutledge J, Fischer-Brown A, VanEtten T, Malusky S, Beebe D. Application of sexed semen technology to in vitro embryo production in cattle. Theriogenology. 2006;65(1):219-27. doi: 10.1016/j.theriogenology.2005.09.032. PubMed PMID: WOS:000234013900020
  146. Toepke M, Beebe D. PDMS absorption of small molecules and consequences in microfluidic applications. Lab on a Chip. 2006;6(12):1484-6. doi: 10.1039/b612140c. PubMed PMID: WOS:000243212600009
  147. Tang H, Beebe D. An oral tactile interface for blind navigation. Ieee Transactions on Neural Systems and Rehabilitation Engineering. 2006;14(1):116-23. doi: 10.1109/tnsre.2005.862696|10.1109/tnsre.2005.86296. PubMed PMID: WOS:000236519000015
  148. Sridharamurthy S, Agarwal A, Beebe D, Jiang H. Dissolvable membranes as sensing elements for microfluidics based biological/chemical sensors. Lab on a Chip. 2006;6(7):840-2. doi: 10.1039/b607066c. PubMed PMID: WOS:000238580900002
  149. Park J, Teren S, Tepp W, Beebe D, Johnson E, Abbott N. Formation of oligopeptide-based polymeric membranes at interfaces between aqueous phases and thermotropic liquid crystals. Chemistry of Materials. 2006;18(26):6147-51. doi: 10.1021/cm0606732. PubMed PMID: WOS:000242935500015
  150. Paguirigan A, Beebe D, Liu B, Alexander C. Mammary stem and progenitor cells: Tumour precursors? European Journal of Cancer. 2006;42(9):1225-36. doi: 10.1016/j.ejca.2006.01.048. PubMed PMID: WOS:000238559700006
  151. Mohanty S, Kim D, Beebe D. Do-it-yourself microelectrophoresis chips with integrated sample recovery. Electrophoresis. 2006;27(19):3772-8. doi: 10.1002/elps.200600238. PubMed PMID: WOS:000241621000010
  152. Kim D, Chesler N, Beebe D. A method for dynamic system characterization using hydraulic series resistance. Lab on a Chip. 2006;6(5):639-44. doi: 10.1039/b517054k. PubMed PMID: WOS:000237229200006
  153. Kim D, Beebe D. A sensing method based on elastic instabilities of swelling hydrogels. 2006 International Conference on Microtechnologies in Medicine and Biology. 2006:292-4. doi: 10.1109/mmb.2006.251553. PubMed PMID: WOS:000244177200087
  154. Kaczmarek K, Nammi K, Agarwal A, Tyler M, Haase S, Beebe D. Polarity effect in electrovibration for tactile display. Ieee Transactions on Biomedical Engineering. 2006;53(10):2047-54. doi: 10.1109/tbme.2006.881804. PubMed PMID: WOS:000240698800021
  155. Eddington D, Puccinelli J, Beebe D. Thermal aging and reduced hydrophobic recovery of polydimethylsiloxane. Sensors and Actuators B-Chemical. 2006;114(1):170-2. doi: 10.1016/j.snb.2005.04.037. PubMed PMID: WOS:000236009300023
  156. Dong L, Agarwal A, Beebe D, Jiang H. Adaptive liquid microlenses activated by stimuli-responsive hydrogels. Nature. 2006;442(7102):551-4. doi: 10.1038/nature05024. PubMed PMID: WOS:000239455900040
  157. Atencia J, Beebe D. Steady flow generation in microcirculatory systems. Lab on a Chip. 2006;6(4):567-74. doi: 10.1039/b514070f. PubMed PMID: WOS:000236386500015
  158. Agarwal A, Beebe D, Jiang H. Integration of polymer and metal microstructures using liquid-phase photopolymerization. Journal of Micromechanics and Microengineering. 2006;16(2):332-40. doi: 10.1088/0960-1317/16/2/018. PubMed PMID: WOS:000235674000018
  159. Abhyankar V, Lokuta M, Huttenlocher A, Beebe D. Characterization of a membrane-based gradient generator for use in cell-signaling studies. Lab on a Chip. 2006;6(3):389-93. doi: 10.1039/b514133h. PubMed PMID: WOS:000235993800008
  160. Zeringue H, Wheeler M, Beebe D. A microfluidic method for removal of the zona pellucida from mammalian embryos. Lab on a Chip. 2005;5(1):108-10. doi: 10.1039/b406703g. PubMed PMID: WOS:000225889000016
  161. Zeringue H, Rutledge J, Beebe D. Early mammalian embryo development depends on cumulus removal technique. Lab on a Chip. 2005;5(1):86-90. doi: 10.1039/b316494m. PubMed PMID: WOS:000225889000012
  162. Yu H, Shkel I, Beebe D, Laurell T, Nilsson J, Jensen K, Harrison D, Kutter J. Effect of microchannel geometry on cell proliferation: Experiments and interpretation. Micro Total Analysis Systems 2004, Vol 1. 2005(296):602-4. PubMed PMID: WOS:000228997000202
  163. Yu H, Meyvantsson I, Shkel I, Beebe D. Diffusion dependent cell behavior in microenvironments. Lab on a Chip. 2005;5(10):1089-95. doi: 10.1039/b504403k. PubMed PMID: WOS:000232003200013
  164. Sridharamurthy S, Agarwal A, Beebe D, Jiang H, IEEE. A fluidic chemical and biological sensing mechanism with high transduction based on dissolvable membranes. Transducers '05, Digest of Technical Papers, Vols 1 and 2. 2005:1820-3. PubMed PMID: WOS:000232189100450
  165. Sershen S, Mensing G, Ng M, Halas N, Beebe D, West J. Independent optical control of microfluidic valves formed from optomechanically responsive nanocomposite hydrogels. Advanced Materials. 2005;17(11):1366-+. doi: 10.1002/adma.200401239. PubMed PMID: WOS:000229718400007
  166. Moorthy J, Bergendahl V, Burgess R, Beebe D, Laurell T, Nilsson J, Jensen K, Harrison D. Hydrogel based environments for biomolecular interaction studies. Micro Total Analysis Systems 2004, Vol 2. 2005(297):240-2. PubMed PMID: WOS:000229017400079
  167. Meyvantsson I, Beebe D, IEEE. High throughput microfluidic system for heterogeneous assays. 2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology. 2005:42-4. doi: 10.1109/mmb.2005.1548379. PubMed PMID: WOS:000234204800016
  168. Kim D, Tyler M, Beebe D. Development of a tongue-operated switch array as an alternative input device. International Journal of Human-Computer Interaction. 2005;18(1):19-38. doi: 10.1207/s15327590ijhc1801_2. PubMed PMID: WOS:000227751300002
  169. Kim D, Mohanty S, Beebe D, Laurell T, Nilsson J, Jensen K, Harrison D, Kutter J. Active assembly methods for microfluidic systems. Micro Total Analysis Systems 2004, Vol 1. 2005(296):36-8. PubMed PMID: WOS:000228997000012
  170. Jeong W, Kim J, Choo J, Lee E, Han C, Beebe D, Seong G, Lee S. Continuous fabrication of biocatalyst immobilized microparticles using photopolymerization and immiscible liquids in microfluidic systems. Langmuir. 2005;21(9):3738-41. doi: 10.1021/la050105l|10.1021/la0501051. PubMed PMID: WOS:000228590800004
  171. Eddington D, Beebe D. Development of a disposable infusion system for the delivery of protein therapeutics. Biomedical Microdevices. 2005;7(3):223-30. doi: 10.1007/s10544-005-3029-2. PubMed PMID: WOS:000231245400008
  172. Clark S, Haubert K, Beebe D, Ferguson C, Wheeler M. Reduction of polyspermic penetration using biomimetic microfluidic technology during in vitro fertilization. Lab on a Chip. 2005;5(11):1229-32. doi: 10.1039/b504397m. PubMed PMID: WOS:000232774900004
  173. Bassetti M, Chatterjee A, Aluru N, Beebe D. Development and modeling of electrically triggered hydrogels for microfluidic applications. Journal of Microelectromechanical Systems. 2005;14(5):1198-207. doi: 10.1109/jmems.2005.845407. PubMed PMID: WOS:000232571000033
  174. Atencia J, Yu H, Beebe D, Laurell T, Nilsson J, Jensen K, Harrison D, Kutter J. Micropump for recirculation of insect cells in suspension. Micro Total Analysis Systems 2004, Vol 1. 2005(296):605-7. PubMed PMID: WOS:000228997000203
  175. Atencia J, Beebe D. Controlled microfluidic interfaces. Nature. 2005;437(7059):648-55. doi: 10.1038/nature04163. PubMed PMID: WOS:000232157900038
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  177. Agarwal A, Sridharamurthy S, Beebe D, Jiang H. Programmable autonomous micromixers and micropumps. Journal of Microelectromechanical Systems. 2005;14(6):1409-21. doi: 10.1109/jmems.2005.859101. PubMed PMID: WOS:000233953000020
  178. Wheeler M, Clark S, Beebe D. Developments in in vitro technologies for swine embryo production. Reproduction Fertility and Development. 2004;16(1-2):15-25. doi: 10.1071/rd03074. PubMed PMID: WOS:000187526900003
  179. Walker G, Zeringue H, Beebe D. Microenvironment design considerations for cellular scale studies. Lab on a Chip. 2004;4(2):91-7. doi: 10.1039/b311214d. PubMed PMID: WOS:000221029900005
  180. Walker G, Ozers M, Beebe D. Cell infection within a microfluidic device using virus gradients. Sensors and Actuators B-Chemical. 2004;98(2-3):347-55. doi: 10.1016/j.snb.2003.10.014. PubMed PMID: WOS:000220214300032
  181. Raty S, Walters E, Davis J, Zeringue H, Beebe D, Rodriguez-Zas S, Wheeler M. Embryonic development in the mouse is enhanced via microchannel culture. Lab on a Chip. 2004;4(3):186-90. doi: 10.1039/b316437c. PubMed PMID: WOS:000221708800008
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  183. Mohanty S, Sohn L, Beebe D, ieee. Hybrid polymer/thin film impedance system for label free monitoring of. Proceedings of the 26th Annual International Conference of the Ieee Engineering in Medicine and Biology Society, Vols 1-7. 2004;26:2561-4. PubMed PMID: WOS:000225461800662
  184. Mensing G, Pearce T, Graham M, Beebe D. An externally driven magnetic microstirrer. Philosophical Transactions of the Royal Society a-Mathematical Physical and Engineering Sciences. 2004;362(1818):1059-68. doi: 10.1098/rsta.2003.1362. PubMed PMID: WOS:000221263000008
  185. Johnson B, Beebe D, Crone W. Effects of swelling on the mechanical properties of a pH-sensitive hydrogel for use in microfluidic devices. Materials Science & Engineering C-Biomimetic and Supramolecular Systems. 2004;24(4):575-81. doi: 10.1016/j.msec.2003.11.002. PubMed PMID: WOS:000221992700019
  186.  Johnson B, Bauer J, Niedermaier D, Crone W, Beebe D. Experimental techniques for mechanical characterization of hydrogels at the microscale. Experimental Mechanics. 2004;44(1):21-8. doi: 10.1007/bf02427971|10.1177/0014485104039629. PubMed PMID: WOS:000188607100003
  187. Jeong W, Kim J, Kim S, Lee S, Mensing G, Beebe D. Hydrodynamic microfabrication via "on the fly'' photopolymerization of microscale fibers and tubes. Lab on a Chip. 2004;4(6):576-80. doi: 10.1039/b411249k. PubMed PMID: WOS:000225382800009
  188. Eddington D, Beebe D. Flow control with hydrogels. Advanced Drug Delivery Reviews. 2004;56(2):199-210. doi: 10.1016/j.addr.2003.08.013. PubMed PMID: WOS:000188777900006
  189. Eddington D, Beebe D. A valved responsive hydrogel microdispensing device with integrated pressure source. Journal of Microelectromechanical Systems. 2004;13(4):586-93. doi: 10.1109/jmems.2004.832190. PubMed PMID: WOS:000223180200005
  190. Bauer J, Saif T, Beebe D. Surface tension driven formation of microstructures. Journal of Microelectromechanical Systems. 2004;13(4):553-8. doi: 10.1109/jmems.2004.832181. PubMed PMID: WOS:000223180200001
  191. Atencia J, Beebe D. Magnetically-driven biomimetic micro pumping using vortices. Lab on a Chip. 2004;4(6):598-602. doi: 10.1039/b407710e. PubMed PMID: WOS:000225382800012
  192. Vijayendran R, Motsegood K, Beebe D, Leckband D. Evaluation of a three-dimensional micromixer in a surface-based biosensor. Langmuir. 2003;19(5):1824-8. doi: 10.1021/la0262250. PubMed PMID: WOS:000181309600050
  193. Tang H, Beebe D. Design and microfabrication of a flexible oral electrotactile display. Journal of Microelectromechanical Systems. 2003;12(1):29-36. doi: 10.1109/jmems.2002.807478. PubMed PMID: WOS:000181346200004
  194. Moorthy J, Beebe D. Organic and biomimetic designs for microfluidic systems - New strategies offer a flexible approach to designing microscale devices. Analytical Chemistry. 2003;75(13):292A-301A. doi: 10.1021/ac0313567. PubMed PMID: WOS:000183975300003
  195. Moorthy J, Beebe D. In situ fabricated porous filters for microsystems. Lab on a Chip. 2003;3(2):62-6. doi: 10.1039/b300450c. PubMed PMID: WOS:000182988000006
  196. Lee S, Jeong W, Beebe D. Microfluidic valve with cored glass microneedle for microinjection. Lab on a Chip. 2003;3(3):164-7. doi: 10.1039/b305692a. PubMed PMID: WOS:000184541100007
  197. Lee S, Eddington D, Kim Y, Kim W, Beebe D. Control mechanism of an organic self-regulating microfluidic system. Journal of Microelectromechanical Systems. 2003;12(6):848-54. doi: 10.1109/jmems.2003.820292. PubMed PMID: WOS:000187936400010
  198. Khoury C, Adalsteinsson T, Johnson B, Crone W, Beebe D. Tunable microfabricated hydrogels - A study in protein interaction and diffusion. Biomedical Microdevices. 2003;5(1):35-45. doi: 10.1023/a:1024411332492. PubMed PMID: WOS:000183771900005
  199. Clark S, Walters E, Beebe D, Wheeler M. Determination of the BSA content needed for culture of porcine embryos fertilized in microchannels. Biology of Reproduction. 2003;68:250-. PubMed PMID: WOS:000183821400390
  200. Zhao B, Viernes N, Moore J, Beebe D. Control and applications of immiscible liquids in microchannels. Journal of the American Chemical Society. 2002;124(19):5284-5. doi: 10.1021/ja025835j. PubMed PMID: WOS:000175521200016
  201. Zhao B, Moore J, Beebe D. Principles of surface-directed liquid flow in microfluidic channels. Analytical Chemistry. 2002;74(16):4259-68. doi: 10.1021/ac020269w. PubMed PMID: WOS:000177502700043
  202. Wang L, Beebe D. Characterization of a silicon-based shear-force sensor on human subjects. Ieee Transactions on Biomedical Engineering. 2002;49(11):1340-7. doi: 10.1109/tbme.2002.804586. PubMed PMID: WOS:000179177000012
  203. Walker G, Ozers M, Beebe D. Insect cell culture in microfluidic channels. Biomedical Microdevices. 2002;4(3):161-6. doi: 10.1023/a:1016088128057. PubMed PMID: WOS:000177776600001
  204. Walker G, Beebe D, Dittmar A, Beebe D. Evaporation-driven microfluidic sample concentration. 2nd Annual International Ieee-Embs Special Topic Conference on Microtechnologies in Medicine & Biology, Proceedings. 2002:523-6. doi: 10.1109/mmb.2002.1002397. PubMed PMID: WOS:000176123400109
  205. Walker G, Beebe D. An evaporation-based microfluidic sample concentration method. Lab on a Chip. 2002;2(2):57-61. doi: 10.1039/b202473j. PubMed PMID: WOS:000178030700004
  206. Walker G, Beebe D. A passive pumping method for microfluidic devices. Lab on a Chip. 2002;2(3):131-4. doi: 10.1039/b204381e. PubMed PMID: WOS:000178030900003
  207. Quirk D, Beebe D, IEEE. Rapid photolithographic fabrication of three dimensional microfluidic devices. Second Joint Embs-Bmes Conference 2002, Vols 1-3, Conference Proceedings. 2002:1820-1. doi: 10.1109/iembs.2002.1053043. PubMed PMID: WOS:000180194800897
  208. Moorthy J, Beebe D, Dittmar A, Beebe D. In situ fabricated porous filter - Characterization and biological applications. 2nd Annual International Ieee-Embs Special Topic Conference on Microtechnologies in Medicine & Biology, Proceedings. 2002:514-7. doi: 10.1109/mmb.2002.1002394. PubMed PMID: WOS:000176123400107
  209. Moorthy J, Beebe D. A hydrogel readout for autonomous detection of ions in microchannels. Lab on a Chip. 2002;2(2):76-80. doi: 10.1039/b110094g. PubMed PMID: WOS:000178030700008
  210. Mensing G, Pearce T, Beebe D, Dittmar A, Beebe D. An in-plane active magnetic mixer for microfluidic applications. 2nd Annual International Ieee-Embs Special Topic Conference on Microtechnologies in Medicine & Biology, Proceedings. 2002:531-4. doi: 10.1109/mmb.2002.1002400. PubMed PMID: WOS:000176123400111
  211. Liu R, Yu Q, Beebe D. Fabrication and characterization of hydrogel-based microvalves. Journal of Microelectromechanical Systems. 2002;11(1):45-53. doi: 10.1109/84.982862. PubMed PMID: WOS:000173751000006
  212. Kim D, Agarwal A, Delisle M, Tyler M, Beebe D, IEEE. Geometric optimization of a tongue-operated switch array. Second Joint Embs-Bmes Conference 2002, Vols 1-3, Conference Proceedings. 2002:2441-2. PubMed PMID: WOS:000180194801197
  213. Khoury C, Mensing G, Beebe D. Ultra rapid prototyping of microfluidic systems using liquid phase photopolymerization. Lab on a Chip. 2002;2(1):50-5. doi: 10.1039/b109344d. PubMed PMID: WOS:000177954900016
  214. Khoury C, Adalsteinson T, Beebe D, Dittmar A, Beebe D. Characterization of protein interaction with tunable microfabricated hydrogels. 2nd Annual International Ieee-Embs Special Topic Conference on Microtechnologies in Medicine & Biology, Proceedings. 2002:400-5. doi: 10.1109/mmb.2002.1002355. PubMed PMID: WOS:000176123400083
  215. Hickman D, Beebe D, Rodriguez-Zas S, Wheeler M. Comparison of static and dynamic medium environments for culturing of pre-implantation mouse embryos. Comparative Medicine. 2002;52(2):122-6. PubMed PMID: WOS:000175291400006
  216. Eddington D, Beebe D, IEEE. A hydrogel actuated microdispensing device. Second Joint Embs-Bmes Conference 2002, Vols 1-3, Conference Proceedings. 2002:1824-5. doi: 10.1109/iembs.2002.1053045. PubMed PMID: WOS:000180194800899
  217. De S, Aluru N, Johnson B, Crone W, Beebe D, Moore J. Equilibrium swelling and kinetics of pH-responsive hydrogels: Models, experiments, and simulations. Journal of Microelectromechanical Systems. 2002;11(5):544-55. doi: 10.1109/jmems.2002.803281. PubMed PMID: WOS:000178451900018
  218. Clark S, Walters E, Beebe D, Wheeler M. In vitro fertilization of porcine oocytes in polydimethylsiloxane (PDMS)-glass microchannels. Biology of Reproduction. 2002;66:312-. PubMed PMID: WOS:000176561900587
  219. Beebe D, Mensing G, Walker G. Physics and applications of microfluidics in biology. Annual Review of Biomedical Engineering. 2002;4:261-86. doi: 10.1146/annurev.bioeng.4.112601.125916. PubMed PMID: WOS:000177827800012
  220. Bassetti M, Moore J, Beebe D, Dittmar A, Beebe D. Development of electrically triggered hydrogels for microfluidic applications. 2nd Annual International Ieee-Embs Special Topic Conference on Microtechnologies in Medicine & Biology, Proceedings. 2002:410-3. doi: 10.1109/mmb.2002.1002358. PubMed PMID: WOS:000176123400085
  221. Agarwal A, Nammi K, Kaczmarek K, Tyler M, Beebe D, Dittmar A, Beebe D. A hybrid natural/artificial electrostatic actuator for tactile stimulation. 2nd Annual International Ieee-Embs Special Topic Conference on Microtechnologies in Medicine & Biology, Proceedings. 2002:341-5. doi: 10.1109/mmb.2002.1002343. PubMed PMID: WOS:000176123400071
  222. Zhao B, Moore J, Beebe D. Surface-directed liquid flow inside microchannels. Science. 2001;291(5506):1023-6. doi: 10.1126/science.291.5506.1023. PubMed PMID: WOS:000166860100040
  223. Zerinque H, Beebe D, Wheeler M. Removal of Cumulus from Mammalian Zygotes using Microfluidic Techniques. Biomedical Microdevices. 2001;3(3):219-24. doi: 10.1023/a:1011463330597. PubMed PMID: WOS:000209018700007
  224. Tang H, Beebe D, Kramer A. A multilevel input system with force-sensitive elements. International Journal of Human-Computer Studies. 2001;54(4):495-507. doi: 10.1006/ijhc.2000.0451. PubMed PMID: WOS:000168420900002
  225. Glasgow I, Zeringue H, Beebe D, Choi S, Lyman J, Chan N, Wheeler M. Handling individual mammalian embryos using microfluidics. Ieee Transactions on Biomedical Engineering. 2001;48(5):570-8. doi: 10.1109/10.918596. PubMed PMID: WOS:000168315200008
  226. Eddington D, Liu R, Moore J, Beebe D. An organic self-regulating microfluidic system. Lab on a Chip. 2001;1(2):96-9. doi: 10.1039/b108078d. PubMed PMID: WOS:000179321900004
  227. Agarwal A, Kim D, Delisle M, Tang H, Tyler M, Beebe D, IEEE. Two-way communication through an oral-based tactile interface: Preliminary results. Proceedings of the 23rd Annual International Conference of the Ieee Engineering in Medicine and Biology Society, Vols 1-4. 2001;23:1468-71. PubMed PMID: WOS:000178871900407
  228. Olsen M, Bauer J, Beebe D. Particle imaging technique for measuring the deformation rate of hydrogel microstructures. Applied Physics Letters. 2000;76(22):3310-2. doi: 10.1063/1.126635. PubMed PMID: WOS:000087239400051
  229. Jo B, Van Lerberghe L, Motsegood K, Beebe D. Three-dimensional micro-channel fabrication in polydimethylsiloxane (PDMS) elastomer. Journal of Microelectromechanical Systems. 2000;9(1):76-81. doi: 10.1109/84.825780. PubMed PMID: WOS:000085857600011
  230. Liu RH, Stremier MA, Sharp KC, Olsen MG, Santiago JG, Adrian RJ, Aref H, Beebe DJ. Passive mixing in a three-dimensional serpentine microchannel. Journal of Microelectromechanical Systems. 2000;9(2):190-197. doi: 10.1109/84.846699.
  231. Folch A, Jo B, Hurtado O, Beebe D, Toner M. Microfabricated elastomeric stencils for micropatterning cell cultures. Journal of Biomedical Materials Research. 2000;52(2):346-53. doi: 10.1002/1097-4636(200011)52:2<346::aid-jbm14>;2-h. PubMed PMID: WOS:000088812900014
  232. Beebe D, Moore J, Yu Q, Liu R, Kraft M, Jo B, Devadoss C. Microfluidic tectonics: A comprehensive construction platform for microfluidic systems. Proceedings of the National Academy of Sciences of the United States of America. 2000;97(25):13488-93. doi: 10.1073/pnas.250273097. PubMed PMID: WOS:000165728800009
  233. Beebe D, Moore J, Bauer J, Yu Q, Liu R, Devadoss C, Jo B. Functional hydrogel structures for autonomous flow control inside microfluidic channels. Nature. 2000;404(6778):588-+. doi: 10.1038/35007047. PubMed PMID: WOS:000086400100049
  234. Chan N, Lyman J, Choi S, Zeringue H, Glasgow I, Beebe D, Wheeler M. Development of an embryo transport and analysis system: Material biocompatability. Theriogenology. 1999;51(1):234-. doi: 10.1016/s0093-691x(99)91793-4. PubMed PMID: WOS:000077865900094
  235. Beebe D, Denton D, Radwin R, Webster J. A silicon-based tactile sensor for finger-mounted applications. Ieee Transactions on Biomedical Engineering. 1998;45(2):151-9. doi: 10.1109/10.661263. PubMed PMID: WOS:000071584700002
  236. Beebe D, Hsieh A, Denton D, Radwin R. A silicon force sensor for robotics and medicine. Sensors and Actuators a-Physical. 1995;50(1-2):55-65. doi: 10.1016/0924-4247(96)80085-9. PubMed PMID: WOS:A1995TV42800009
  237. BEEBE D, HSIEH A, DENTON D, Sheppard N, Eden M, Kantor G. A FINGER-MOUNTED SILICON TACTILE SENSOR. Proceedings of the 16th Annual International Conference of the Ieee Engineering in Medicine and Biology Society - Engineering Advances: New Opportunities For Biomedical Engineers, Pts 1&2. 1994:834-5. doi: 10.1109/iembs.1994.415169. PubMed PMID: WOS:A1994BC56Q00417
  238. BEEBE D, DENTON D. A FLEXIBLE POLYIMIDE-BASED PACKAGE FOR SILICON SENSORS. Sensors and Actuators a-Physical. 1994;44(1):57-64. doi: 10.1016/0924-4247(93)00775-y. PubMed PMID: WOS:A1994PB85500009
  239. Microbial volatile communication in human organotypic lung models.

    Barkal LJ, Procknow CL, Álvarez-García YR, Niu M, Jiménez-Torres JA, Brockman-Schneider RA, Gern JE, Denlinger LC, Theberge AB, Keller NP, Berthier E, Beebe DJ.

    Nat Commun. 2017 Nov 24;8(1):1770. doi: 10.1038/s41467-017-01985-4.

    PMID: 29176665

  240. RNA-mediated TILDA for improved cell capacity and enhanced detection of multiply-spliced HIV RNA.

    Pezzi HM, Berry SM, Beebe DJ, Striker R.

    Integr Biol (Camb). 2017 Nov 13;9(11):876-884. doi: 10.1039/c7ib00112f.

    PMID: 29098230

  241. Human papillomavirus oncogenes reprogram the cervical cancer microenvironment independently of and synergistically with estrogen.

    Spurgeon ME, den Boon JA, Horswill M, Barthakur S, Forouzan O, Rader JS, Beebe DJ, Roopra A, Ahlquist P, Lambert PF.

    Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):E9076-E9085. doi: 10.1073/pnas.1712018114. Epub 2017 Oct 9.

    PMID: 29073104

  242. Adaptation of a Simple Microfluidic Platform for High-Dimensional Quantitative Morphological Analysis of Human Mesenchymal Stromal Cells on Polystyrene-Based Substrates.

    SLAS Technol. 2017 Dec;22(6):646-661. doi: 10.1177/2472630317726050. Epub 2017 Aug 21.

    Lam J1, Marklein RA1, Jimenez-Torres JA2, Beebe DJ2, Bauer SR1, Sung KE1.